F2R

Across TCGA patient cohorts, F2R mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible F2R-associated genes across cancer lineages are Rad50, Caspase-7-cleavedD198, and c-Kit. Each is linked with F2R in more than 1 cancer types. Because this analysis shows association rather than direction, both F2R-to-partner and partner-to-F2R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by F2R-low versus F2R-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (F2R→partner) and Y-score (partner→F2R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.197	-2.986	.043	.035	3	2
UCEC	Caspase-7-cleavedD198 →	+0.670	+1.894	.004	.030	3	2
UCEC	c-Kit →	-0.198	-2.680	.034	.006	3	2
UCEC	14-3-3_beta →	-0.095	-2.295	.019	.033	3	1
UCEC	EGFR_pY1068 →	-0.306	-2.415	.002	.003	3	1
UCEC	eIF4E →	+0.211	+3.584	.012	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Rad50 by F2R expression — UCEC

Explore this box plot interactively →