F2R

Across TCGA cell cohorts, F2R mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible F2R-associated genes across cancer lineages are PRAMEF27, OR10AG1, and RFPL3. Each is linked with F2R in more than 1 cancer types. Because this analysis shows association rather than direction, both F2R-to-partner and partner-to-F2R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF27 grouped by F2R-low versus F2R-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (F2R→partner) and Y-score (partner→F2R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PRAMEF27 →	+0.020	+5.643	<.001	.002	3	1
OVARY	OR10AG1 →	+0.020	+5.807	<.001	.001	3	1
LARGE_INTESTINE	RFPL3 →	+0.053	+3.510	<.001	.003	3	1
LARGE_INTESTINE	COX6A2 →	+0.068	+4.022	<.001	.006	3	1
LARGE_INTESTINE	LRRC3B →	+0.018	+3.345	<.001	.007	3	1
LARGE_INTESTINE	PRR23B →	+0.004	+3.632	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

PRAMEF27 by F2R expression — LUNG_SCLC

Explore this box plot interactively →