F13B

Across TCGA pan-cancer cohorts, F13B mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of F13B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where F13B mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types F13B is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, LUAD, and COAD are the cancer types where F13B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in F13B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−1.059	<.001	11	view →
LUAD	Female	III,IV	−1.190	<.001	9	view →
COAD	Male	III,IV	−0.794	<.001	9	view →
LSCC	Male	II,III,IV	−1.154	<.001	8	view →
OV	All	All	−0.726	.017	2	view →
PDAC	Male	IV	−0.975	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

F13B–HNSC

Open the HNSC breakdown →