F13A1

Across TCGA patient cohorts, F13A1 mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible F13A1-associated genes across cancer lineages are SETD2, eIF4E, and ATM. Each is linked with F13A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both F13A1-to-partner and partner-to-F13A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SETD2 grouped by F13A1-low versus F13A1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (F13A1→partner) and Y-score (partner→F13A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SETD2 →	-0.128	-1.906	.026	.016	3	3
UCEC	eIF4E →	+0.192	+3.820	.002	<.001	3	3
UCEC	ATM →	-0.550	-2.986	<.001	<.001	3	3
UCEC	C-Raf →	+0.145	+1.736	<.001	.006	3	3
LUSC	Ku80 →	+0.393	+2.834	.036	.035	3	2
LUSC	p70-S6K →	+0.369	+2.816	.005	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

SETD2 by F13A1 expression — SKCM

Explore this box plot interactively →