F12

Across TCGA patient cohorts, F12 protein abundance is significantly associated with the RNA expression of many other genes, with 11,697 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible F12-associated genes across cancer lineages are COL6A3, LINC00924, and PDGFB. Each is linked with F12 in more than 6 cancer types. Because this analysis shows association rather than direction, both F12-to-partner and partner-to-F12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, F12 versus COL6A3 in GBM, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (F12→partner) and Y-score (partner→F12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	COL6A3 →	+1.914	+0.497	<.001	.005	3	7
OV	LINC00924 →	+0.643	+0.796	<.001	<.001	3	7
OV	PDGFB →	+1.270	+0.709	<.001	<.001	3	6
BRCA	CCN4 →	+1.423	+0.753	<.001	<.001	3	6
OV	SYDE1 →	+1.130	+0.661	<.001	.001	3	6
CCRCC	SEPTIN4 →	+0.731	+0.656	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,697 associations by consensus.

F12 vs COL6A3 — GBM

Explore this scatter interactively →