F12

Across TCGA pan-cancer cohorts, F12 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated F12 data layer compared with 2 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher F12 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated F12 expression acts as an unfavorable survival marker, although some lineages such as LIHC and READ show a favorable association.

ACC, UVM, and MESO are the cancer types where F12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.176	0.703	<.001	141	view →
UVM	DFS	Median	All	0.417	0.748	<.001	136	view →
MESO	OS	Median	All	0.243	0.515	<.001	111	view →
THCA	OS	Tertile	All	0.941	0.995	.001	67	view →
UCS	DFS	Median	II,III,IV	0.213	0.505	.006	56	view →
LAML	DFS	Tertile	All	0.203	0.520	<.001	48	view →
LUAD	DFS	Quartile	All	0.578	0.736	.001	42	view →
LIHC	OS	Quartile	All	0.855	0.612	<.001	41	view →
SKCM	OS	Tertile	All	0.831	0.911	.003	38	view →
UCEC	OS	Quartile	II,III,IV	0.640	0.848	.004	26	view →
READ	DFS	Quartile	IV	0.855	0.384	.004	20	view →
BRCA	DFS	Quartile	All	0.853	0.932	.001	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

F12–ACC (DFS)

Open the ACC breakdown →