F12

Across TCGA patient cohorts, F12 protein abundance is significantly associated with the protein abundance of many other proteins, with 21,598 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible F12-associated proteins across cancer lineages are A1BG, BGN, and C1R. Each is linked with F12 in more than 9 cancer types. Because this analysis shows association rather than direction, both F12-to-partner and partner-to-F12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, F12 versus A1BG in CCRCC, with a Pearson correlation of 0.79.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (F12→partner) and Y-score (partner→F12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	A1BG →	+0.733	+0.701	<.001	<.001	3	10
BRCA	BGN →	+0.829	+0.647	<.001	<.001	3	10
OV	C1R →	+0.641	+0.488	<.001	<.001	3	10
BRCA	C1S →	+0.580	+0.514	<.001	<.001	3	10
PDAC	C2 →	+0.699	+0.625	<.001	<.001	3	10
CCRCC	C3 →	+0.726	+0.726	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,598 associations by consensus.

F12 vs A1BG — CCRCC

Explore this scatter interactively →