F12

Across TCGA patient cohorts, F12 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible F12-associated genes across cancer lineages are JNK2, Ku80, and p21. Each is linked with F12 in more than 1 cancer types. Because this analysis shows association rather than direction, both F12-to-partner and partner-to-F12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by F12-low versus F12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (F12→partner) and Y-score (partner→F12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.358	+3.169	.001	.020	3	2
UCEC	Ku80 →	+0.361	+3.183	.005	.010	3	1
UCEC	p21 →	+0.259	+3.169	.014	.020	3	1
UCEC	p27_pT157 →	-0.074	-3.169	.019	.020	3	1
UCEC	p62 Lck ligand →	+0.379	+3.179	.034	.010	3	1
UCEC	PDCD4 →	-0.607	-3.169	.018	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

JNK2 by F12 expression — UCEC

Explore this box plot interactively →