F12

Across TCGA cell cohorts, F12 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,311 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible F12-associated GO terms across cancer lineages are Kinin cascade, Plasma kallikrein-kinin cascade, and Factor XII activation. Each is linked with F12 in more than 19 cancer types. Because this analysis shows association rather than direction, both F12-to-partner and partner-to-F12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Kinin cascade grouped by F12-low versus F12-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (F12→partner) and Y-score (partner→F12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Kinin cascade →	+1.688	+2.164	<.001	<.001	3	20
LUNG_NSCLC_LUSC	Plasma kallikrein-kinin cascade →	+1.688	+2.164	<.001	<.001	3	20
LUNG_NSCLC_LUSC	Factor XII activation →	+1.688	+2.164	<.001	<.001	3	20
URINARY_TRACT	Positive regulation of fibrinolysis →	+1.827	+1.780	<.001	<.001	3	20
SOFT_TISSUE	Glucose metabolic process →	+0.080	+1.390	<.001	<.001	3	9
LUNG_SCLC	Purine nucleoside triphosphate metabolic process →	+0.087	+1.432	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,311 associations by consensus.

Kinin cascade by F12 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →