F12

Across TCGA cell cohorts, F12 mutation is significantly associated with the RNA expression of many other genes, with 45 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible F12-associated genes across cancer lineages are SLC32A1, GML, and IL17F. Each is linked with F12 in more than 1 cancer types. Because this analysis shows association rather than direction, both F12-to-partner and partner-to-F12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC32A1 grouped by F12-low versus F12-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (F12→partner) and Y-score (partner→F12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC32A1 →	+1.026	+3.901	<.001	.006	3	1
BLOOD_Leukemia	GML →	+0.058	+4.567	.002	.001	3	1
BLOOD_Leukemia	IL17F →	+0.063	+3.855	<.001	.007	3	1
BLOOD_Leukemia	TCF21 →	+0.010	+3.705	<.001	.007	3	1
BLOOD_Leukemia	GFRA4 →	+0.563	+4.824	<.001	<.001	3	1
BLOOD_Leukemia	TSHB →	+0.115	+4.691	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

SLC32A1 by F12 expression — BLOOD_Leukemia

Explore this box plot interactively →