F11-AS1

Across TCGA pan-cancer cohorts, F11-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of F11-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where F11-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types F11-AS1 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and KICH are the cancer types where F11-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in F11-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−2.341	<.001	12	view →
KIRP	Male	III,IV	−2.634	<.001	11	view →
KICH	Male	All	−2.886	<.001	10	view →
LUSC	Female	II,III,IV	−1.380	<.001	9	view →
LUAD	Male	All	−1.083	<.001	9	view →
LIHC	All	All	−0.622	<.001	4	view →
THCA	Male	III,IV	−0.127	.008	4	view →
CHOL	All	All	−2.582	<.001	3	view →
HNSC	Male	II,III,IV	+0.083	.029	2	view →
BRCA	All	III,IV	−0.024	.021	2	view →
READ	All	II,III,IV	−0.125	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

F11-AS1–KIRC

Open the KIRC breakdown →