F10

Across TCGA pan-cancer cohorts, F10 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of F10’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where F10 RNA is repressed in tumor relative to normal tissue. In most cancer types F10 is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

BLCA, THCA, and LUAD are the cancer types where F10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in F10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−3.932	<.001	11	view →
THCA	Male	IV	−2.476	<.001	11	view →
LUAD	Female	III,IV	−2.110	<.001	9	view →
LUSC	Male	II,III,IV	−2.321	<.001	8	view →
HNSC	Male	IV	−1.804	<.001	8	view →
UCEC	All	III,IV	−3.714	<.001	6	view →
BRCA	All	II,III,IV	−2.146	<.001	6	view →
STAD	Male	All	−1.306	.001	5	view →
KIRC	All	III,IV	+1.082	.006	5	view →
KICH	All	All	−0.523	.003	5	view →
CHOL	All	All	−2.891	<.001	3	view →
READ	Female	All	−1.198	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

F10–BLCA

Open the BLCA breakdown →