F10

Across TCGA pan-cancer cohorts, F10 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of F10’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where F10 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types F10 is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, LUAD, and LSCC are the cancer types where F10 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in F10 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−1.337	<.001	11	view →
LUAD	Female	III,IV	−1.547	<.001	9	view →
LSCC	Female	II,III,IV	−1.322	<.001	8	view →
COAD	Female	II,III,IV	−0.420	<.001	6	view →
CCRCC	All	II,III,IV	−0.223	.049	2	view →
PDAC	Female	All	+0.327	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

F10–HNSC

Open the HNSC breakdown →