F10-AS1

Across TCGA pan-cancer cohorts, F10-AS1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of F10-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where F10-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types F10-AS1 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and KIRP are the cancer types where F10-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in F10-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.664	<.001	11	view →
THCA	Male	II,III,IV	−0.301	<.001	9	view →
KIRP	Male	All	−0.616	<.001	7	view →
BRCA	Female	All	+0.091	.028	4	view →
CHOL	All	All	−0.580	<.001	2	view →
KICH	Female	All	+0.543	<.001	2	view →
UCEC	All	II,III,IV	−0.275	.033	2	view →
LUSC	All	All	+0.093	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

F10-AS1–KIRC

Open the KIRC breakdown →