EZR-AS1

Across TCGA pan-cancer cohorts, EZR-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated EZR-AS1 data layer.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher EZR-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated EZR-AS1 expression acts as an unfavorable survival marker, although some lineages such as READ and CHOL show a favorable association.

READ, DLBC, and ESCA are the cancer types where EZR-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	DFS	Tertile	II,III,IV	0.730	0.376	.003	31	view →
DLBC	DFS	Median	II,III,IV	0.567	0.971	.016	21	view →
ESCA	OS	Tertile	II,III,IV	0.566	0.767	.007	18	view →
CHOL	OS	Median	All	0.792	0.392	.023	18	view →
LUAD	OS	Median	III,IV	0.434	0.215	.012	17	view →
MESO	DFS	Quartile	IV	0.068	0.535	.006	15	view →
THYM	DFS	Median	II,III,IV	0.934	0.761	.007	11	view →
UVM	DFS	Median	All	0.632	0.833	.024	10	view →
STAD	OS	Quartile	III,IV	0.734	0.340	.003	9	view →
LGG	OS	Quartile	All	0.967	0.843	.001	7	view →
KIRC	DFS	Median	IV	0.409	0.583	.020	6	view →
BLCA	OS	Quartile	II,III,IV	0.776	0.673	.037	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

EZR-AS1–READ (DFS)

Open the READ breakdown →