EZR-AS1

Across TCGA pan-cancer cohorts, EZR-AS1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of EZR-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where EZR-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types EZR-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, COAD, and KICH are the cancer types where EZR-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EZR-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.635	<.001	5	view →
COAD	Female	All	+0.576	.002	4	view →
KICH	All	All	−0.453	.001	4	view →
KIRP	All	IV	−0.520	.030	2	view →
READ	All	III,IV	+0.375	<.001	2	view →
PRAD	All	All	+0.328	.001	2	view →
LUSC	All	All	−0.206	.029	2	view →
LUAD	Female	II,III,IV	−0.492	.003	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

EZR-AS1–THCA

Open the THCA breakdown →