Across TCGA patient cohorts, EZHIP mutation is significantly associated with the RNA expression of many other genes, with 2,120 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EZHIP-associated genes across cancer lineages are CEP55, MYO19, and PDZD8. Each is linked with EZHIP in more than 3 cancer types. Because this analysis shows association rather than direction, both EZHIP-to-partner and partner-to-EZHIP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EZHIP→partner) and Y-score (partner→EZHIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CEP55 →	+0.503	+2.070	.007	.001	3	4
UCEC	MYO19 →	+0.515	+2.387	<.001	<.001	3	4
SKCM	PDZD8 →	+0.704	+3.610	<.001	.001	3	3
SKCM	SAAL1 →	+0.545	+2.019	<.001	.005	3	3
SKCM	CRK →	+0.460	+3.469	.007	.002	3	3
SKCM	TSR1 →	+0.465	+3.604	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,120 associations by consensus.

Exploration

EZHIP survival (RNA) · tumor vs normal (RNA) · all EZHIP data types