Across TCGA pan-cancer cohorts, EZHIP RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of EZHIP’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where EZHIP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EZHIP is over-expressed in tumor, although a few such as COAD and ESCA show the opposite, repressed pattern.

KIRC, COAD, and ESCA are the cancer types where EZHIP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EZHIP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.081	<.001	6	view →
COAD	Male	All	−0.037	.003	4	view →
ESCA	All	II,III,IV	−0.120	.006	2	view →
LIHC	All	All	+0.153	.014	1	view →
LUSC	Female	II,III,IV	−0.090	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: EZHIP RNA expression & survival · all EZHIP data types