EZHIP

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, EZHIP mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EZHIP-associated genes across cancer lineages are JNK_pT183_Y185, PCNA, and eEF2. Each is linked with EZHIP in more than 2 cancer types. Because this analysis shows association rather than direction, both EZHIP-to-partner and partner-to-EZHIP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EZHIP→partner) and Y-score (partner→EZHIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECJNK_pT183_Y185 →-0.197-2.308<.001<.00133
UCECPCNA →+0.178+2.222.010.01033
UCECeEF2 →+0.345+2.584.002.01032
UCECeIF4E →+0.220+3.169.001<.00132
UCECFoxM1 →+0.172+1.222.040.03532
UCECFOXO3a_pS318_S321 →-0.110-1.999.006.00832
Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Exploration