Across TCGA cell cohorts, EZHIP mutation is significantly associated with the RNA expression of many other genes, with 225 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EZHIP-associated genes across cancer lineages are DEFB108B, SCGB1C1, and IL36A. Each is linked with EZHIP in more than 1 cancer types. Because this analysis shows association rather than direction, both EZHIP-to-partner and partner-to-EZHIP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EZHIP→partner) and Y-score (partner→EZHIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DEFB108B →	+0.161	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	SCGB1C1 →	+0.098	+4.539	<.001	.007	3	1
LUNG_SCLC	IL36A →	+0.020	+4.643	<.001	.004	3	1
LUNG_SCLC	OR7G3 →	+0.047	+4.643	<.001	.004	3	1
LUNG_SCLC	FAM25A →	+0.140	+4.643	<.001	.004	3	1
LUNG_SCLC	HTN3 →	+0.074	+4.269	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 225 associations by consensus.

Exploration

EZHIP survival (RNA) · tumor vs normal (RNA) · all EZHIP data types