EZH2

Across TCGA patient cohorts, EZH2 RNA expression is significantly associated with the protein abundance of many other proteins, with 25,139 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible EZH2-associated proteins across cancer lineages are TNPO3, TOP2A_S1106, and TOP2A_S1247. Each is linked with EZH2 in more than 9 cancer types. Because this analysis shows association rather than direction, both EZH2-to-partner and partner-to-EZH2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EZH2 versus TNPO3 in BRCA, with a Pearson correlation of 0.64.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (EZH2→partner) and Y-score (partner→EZH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TNPO3 →	+0.352	+0.764	<.001	<.001	3	10
LUAD	TOP2A_S1106 →	+1.224	+0.885	<.001	<.001	3	10
LUAD	TOP2A_S1247 →	+1.456	+0.860	<.001	<.001	3	10
GBM	POLD1 →	+0.425	+0.960	<.001	<.001	3	10
LUAD	RPL12_S38 →	+1.161	+0.940	<.001	<.001	3	10
LUAD	RRM2 →	+0.877	+0.924	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 25,139 associations by consensus.

EZH2 vs TNPO3 — BRCA

Explore this scatter interactively →