Across TCGA patient cohorts, EYS mutation is significantly associated with the total protein of many other genes, with 90 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EYS-associated genes across cancer lineages are Cyclin-B1, ACVRL1, and TFRC. Each is linked with EYS in more than 4 cancer types. Because this analysis shows association rather than direction, both EYS-to-partner and partner-to-EYS results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EYS→partner) and Y-score (partner→EYS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.602	+1.707	<.001	<.001	3	5
COAD	ACVRL1 →	-0.225	-3.683	.002	.001	3	5
LUSC	TFRC →	+0.717	+3.459	.001	.004	3	4
BRCA	eIF4G →	+0.408	+2.812	.023	.037	3	4
ESCA	4E-BP1 →	+0.503	+2.999	<.001	.023	3	4
COAD	ASNS →	+0.343	+1.724	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 90 associations by consensus.

Exploration

EYS survival (RNA) · tumor vs normal (RNA) · all EYS data types