Across TCGA cell cohorts, EYS mutation is significantly associated with the RNA expression of many other genes, with 1,326 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EYS-associated genes across cancer lineages are MTFMT, PCCB, and HSD17B13. Each is linked with EYS in more than 2 cancer types. Because this analysis shows association rather than direction, both EYS-to-partner and partner-to-EYS results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EYS→partner) and Y-score (partner→EYS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MTFMT →	+0.454	+1.807	.001	.001	3	3
LARGE_INTESTINE	PCCB →	+0.583	+1.845	<.001	<.001	3	3
SKIN	HSD17B13 →	+0.081	+2.643	.001	.006	3	3
LARGE_INTESTINE	WRAP53 →	+0.460	+1.765	.001	<.001	3	3
LARGE_INTESTINE	RPL22L1 →	+1.331	+2.700	<.001	<.001	3	3
LARGE_INTESTINE	CYB5D1 →	+0.990	+1.502	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,326 associations by consensus.

Exploration

EYS survival (RNA) · tumor vs normal (RNA) · all EYS data types