EYA3

Across TCGA pan-cancer cohorts, EYA3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated EYA3 data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher EYA3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated EYA3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and OV show a favorable association.

LSCC, OV, and CCRCC are the cancer types where EYA3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.903	0.714	.006	17	view →
OV	DFS	Tertile	All	1.000	0.766	.014	12	view →
CCRCC	OS	Median	II,III,IV	0.867	1.000	.032	1	view →
HNSC	DFS	Median	III,IV	0.937	1.000	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

EYA3–LSCC (OS)

Open the LSCC breakdown →