EYA3

Across TCGA patient cohorts, EYA3 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EYA3-associated genes across cancer lineages are INPP4B, JNK2, and Ku80. Each is linked with EYA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EYA3-to-partner and partner-to-EYA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by EYA3-low versus EYA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EYA3→partner) and Y-score (partner→EYA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.319	-3.459	.028	.005	3	1
UCEC	JNK2 →	+0.181	+2.834	.043	.034	3	1
UCEC	Ku80 →	+0.273	+2.179	.010	.034	3	1
UCEC	Notch1 →	+0.141	+2.000	.026	.032	3	1
UCEC	p21 →	+0.179	+2.000	.039	.032	3	1
UCEC	p62 Lck ligand →	+0.293	+2.700	.046	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

INPP4B by EYA3 expression — UCEC

Explore this box plot interactively →