EYA2

Across TCGA cell cohorts, EYA2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,908 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible EYA2-associated GO terms across cancer lineages are Mesodermal cell fate specification, Morphogenesis of an epithelial fold, and Epigenetic regulation of gene expression. Each is linked with EYA2 in more than 11 cancer types. Because this analysis shows association rather than direction, both EYA2-to-partner and partner-to-EYA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mesodermal cell fate specification grouped by EYA2-low versus EYA2-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EYA2→partner) and Y-score (partner→EYA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Mesodermal cell fate specification →	+1.643	+3.558	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Morphogenesis of an epithelial fold →	+1.389	+2.654	.004	.003	3	8
CNS	Epigenetic regulation of gene expression →	+0.042	+1.432	<.001	<.001	3	8
SOFT_TISSUE	Chromosomal 5-methylcytosine DNA demethylation pathway →	+0.102	+1.434	<.001	<.001	3	7
SOFT_TISSUE	Regulatory ncRNA-mediated gene silencing →	+0.065	+2.270	.004	<.001	3	7
OESOPHAGUS	Ribosomal small subunit assembly →	+0.080	+2.195	.009	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,908 associations by consensus.

Mesodermal cell fate specification by EYA2 expression — BLOOD_Myeloma

Explore this box plot interactively →