EYA2

Across TCGA pan-cancer cohorts, EYA2 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated EYA2 data layer compared with 9 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher EYA2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated EYA2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and KIRP show a favorable association.

UCEC, ACC, and LGG are the cancer types where EYA2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.795	0.621	<.001	78	view →
ACC	OS	Tertile	II,III,IV	0.776	1.000	<.001	63	view →
LGG	DFS	Median	All	0.659	0.813	<.001	44	view →
THCA	DFS	Quartile	All	0.802	0.935	.003	44	view →
KIRP	OS	Quartile	II,III,IV	0.931	0.350	.005	38	view →
SKCM	OS	Tertile	All	0.910	0.843	.013	35	view →
HNSC	DFS	Tertile	IV	0.725	0.544	.003	24	view →
LAML	DFS	Tertile	All	0.685	0.357	.006	24	view →
UVM	DFS	Median	All	0.401	0.715	.005	22	view →
SCLC	OS	Quartile	II,III,IV	0.673	0.295	.009	12	view →
STAD	OS	Tertile	IV	0.760	0.213	.041	12	view →
CESC	OS	Quartile	II,III,IV	0.923	0.672	.013	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

EYA2–UCEC (OS)

Open the UCEC breakdown →