EYA2

Across TCGA cell cohorts, EYA2 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EYA2-associated genes across cancer lineages are SPATA31A5, OR2L8, and OPN1LW. Each is linked with EYA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EYA2-to-partner and partner-to-EYA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA31A5 grouped by EYA2-low versus EYA2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EYA2→partner) and Y-score (partner→EYA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SPATA31A5 →	+0.013	+5.029	<.001	.006	3	1
LUNG_SCLC	OR2L8 →	+0.155	+5.029	<.001	.006	3	1
LUNG_NSCLC_LUAD	OPN1LW →	+0.038	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	TEX33 →	+0.018	+4.266	<.001	.004	3	1
LARGE_INTESTINE	CBY1 →	+0.759	+3.160	<.001	.006	3	1
LARGE_INTESTINE	RFX4 →	+0.042	+3.621	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

SPATA31A5 by EYA2 expression — LUNG_SCLC

Explore this box plot interactively →