EXTL3

Across TCGA patient cohorts, EXTL3 protein abundance is significantly associated with the RNA expression of many other genes, with 4,466 significant associations in total. GBM shows the largest number of these associations.

The most reproducible EXTL3-associated genes across cancer lineages are FZD3, PZP, and KLRG1. Each is linked with EXTL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both EXTL3-to-partner and partner-to-EXTL3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EXTL3 versus FZD3 in OV, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXTL3→partner) and Y-score (partner→EXTL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FZD3 →	+0.880	+0.318	.002	.002	3	3
LUAD	PZP →	-0.975	-0.477	<.001	<.001	3	3
HNSC	KLRG1 →	-0.679	-0.389	.007	.004	3	3
HNSC	MBNL1-AS1 →	-0.594	-0.436	.004	.003	3	3
GBM	PPIAP70 →	-0.420	-0.352	.002	<.001	3	3
LUAD	EXTL3-AS1 →	+0.679	+0.472	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,466 associations by consensus.

EXTL3 vs FZD3 — OV

Explore this scatter interactively →