EXTL3

Across TCGA cell cohorts, EXTL3 mutation is significantly associated with the RNA expression of many other genes, with 542 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EXTL3-associated genes across cancer lineages are SEPTIN3, MTPAP, and FAM149A. Each is linked with EXTL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXTL3-to-partner and partner-to-EXTL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEPTIN3 grouped by EXTL3-low versus EXTL3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXTL3→partner) and Y-score (partner→EXTL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SEPTIN3 →	+1.148	+2.714	.001	.002	3	2
LARGE_INTESTINE	MTPAP →	+0.627	+3.743	<.001	<.001	3	2
LARGE_INTESTINE	FAM149A →	+1.309	+2.628	<.001	.002	3	2
LARGE_INTESTINE	NUP43 →	+0.519	+3.743	.002	<.001	3	2
LARGE_INTESTINE	AOC3 →	+0.629	+2.628	<.001	.002	3	2
LARGE_INTESTINE	BBS7 →	+0.569	+3.523	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 542 associations by consensus.

SEPTIN3 by EXTL3 expression — LARGE_INTESTINE

Explore this box plot interactively →