EXTL3-AS1

Across TCGA pan-cancer cohorts, EXTL3-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of EXTL3-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where EXTL3-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EXTL3-AS1 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

LIHC, COAD, and KICH are the cancer types where EXTL3-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EXTL3-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	All	+0.200	<.001	8	view →
COAD	Male	All	+0.297	<.001	7	view →
KICH	Female	All	−0.304	<.001	6	view →
LUSC	All	All	+0.260	<.001	5	view →
BRCA	Female	All	−0.211	<.001	4	view →
LUAD	All	All	+0.182	.001	4	view →
CHOL	All	All	+0.346	<.001	3	view →
READ	All	All	+0.320	.003	3	view →
HNSC	All	II,III,IV	+0.057	.026	2	view →
KIRC	Male	III,IV	−0.047	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

EXTL3-AS1–LIHC

Open the LIHC breakdown →