EXT2

Across TCGA patient cohorts, EXT2 protein abundance is significantly associated with the RNA expression of many other genes, with 4,097 significant associations in total. GBM shows the largest number of these associations.

The most reproducible EXT2-associated genes across cancer lineages are SERPINH1, PLOD1, and MSRB3. Each is linked with EXT2 in more than 3 cancer types. Because this analysis shows association rather than direction, both EXT2-to-partner and partner-to-EXT2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EXT2 versus SERPINH1 in GBM, with a Pearson correlation of 0.28.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXT2→partner) and Y-score (partner→EXT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SERPINH1 →	+0.628	+0.180	<.001	.002	3	4
GBM	PLOD1 →	+0.678	+0.250	<.001	<.001	3	3
OV	MSRB3 →	+1.018	+0.322	.001	.001	3	3
OV	CAVIN1 →	+0.863	+0.247	.002	.001	3	3
OV	EXT1 →	+0.547	+0.277	.006	.003	3	3
OV	HOMER3 →	+0.790	+0.232	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,097 associations by consensus.

EXT2 vs SERPINH1 — GBM

Explore this scatter interactively →