EXT1

Across TCGA patient cohorts, EXT1 protein abundance is significantly associated with the RNA expression of many other genes, with 3,227 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible EXT1-associated genes across cancer lineages are TUBB6, LOXL2, and UCN2. Each is linked with EXT1 in more than 3 cancer types. Because this analysis shows association rather than direction, both EXT1-to-partner and partner-to-EXT1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EXT1 versus TUBB6 in CCRCC, with a Pearson correlation of 0.84.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXT1→partner) and Y-score (partner→EXT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TUBB6 →	+0.834	+1.120	.003	<.001	3	4
OV	LOXL2 →	+1.258	+0.600	.003	.007	3	4
HNSC	UCN2 →	+0.763	+0.296	<.001	<.001	3	4
CCRCC	ARSI →	+1.135	+0.756	.004	<.001	2	4
OV	TWIST1 →	+1.185	+0.603	.006	.006	3	3
OV	SPHK1 →	+1.088	+0.645	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,227 associations by consensus.

EXT1 vs TUBB6 — CCRCC

Explore this scatter interactively →