EXOSC9

Across TCGA patient cohorts, EXOSC9 mutation is significantly associated with the RNA expression of many other genes, with 3,830 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXOSC9-associated genes across cancer lineages are FAM230J, RNA5SP64, and MED28P8. Each is linked with EXOSC9 in more than 2 cancer types. Because this analysis shows association rather than direction, both EXOSC9-to-partner and partner-to-EXOSC9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM230J grouped by EXOSC9-low versus EXOSC9-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOSC9→partner) and Y-score (partner→EXOSC9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	FAM230J →	+0.026	+6.257	<.001	.001	3	3
SKCM	RNA5SP64 →	+0.184	+4.199	<.001	.009	3	3
READ	MED28P8 →	+0.246	+5.039	<.001	.008	3	2
SKCM	TRAJ40 →	+0.368	+3.449	.007	.009	3	2
SKCM	TEX36-AS1 →	+0.033	+4.624	<.001	.005	3	2
SKCM	PPP1R3A →	+0.031	+4.899	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,830 associations by consensus.

FAM230J by EXOSC9 expression — READ

Explore this box plot interactively →