EXOSC9

Across TCGA cell cohorts, EXOSC9 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EXOSC9-associated genes across cancer lineages are MSGN1, S100G, and TAFA1. Each is linked with EXOSC9 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXOSC9-to-partner and partner-to-EXOSC9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by EXOSC9-low versus EXOSC9-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOSC9→partner) and Y-score (partner→EXOSC9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.080	+3.760	<.001	<.001	3	1
LARGE_INTESTINE	S100G →	+0.849	+3.103	.005	.004	3	1
LARGE_INTESTINE	TAFA1 →	+0.241	+4.009	.001	<.001	3	1
LARGE_INTESTINE	C14orf180 →	+0.144	+3.155	<.001	.008	3	1
LARGE_INTESTINE	KRTAP10-3 →	+0.036	+3.242	.001	.003	3	1
LARGE_INTESTINE	RBMY1J →	+0.005	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MSGN1 by EXOSC9 expression — LARGE_INTESTINE

Explore this box plot interactively →