EXOSC8

Across TCGA patient cohorts, EXOSC8 mutation is significantly associated with the RNA expression of many other genes, with 105 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXOSC8-associated genes across cancer lineages are MIR3648-1, ELOA3CP, and MIR934. Each is linked with EXOSC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXOSC8-to-partner and partner-to-EXOSC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3648-1 grouped by EXOSC8-low versus EXOSC8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOSC8→partner) and Y-score (partner→EXOSC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR3648-1 →	+0.998	+6.547	<.001	.001	3	2
BRCA	ELOA3CP →	+0.024	+7.731	<.001	.009	3	1
BLCA	MIR934 →	+0.896	+5.685	<.001	.003	3	1
BLCA	MIR541 →	+0.686	+6.618	<.001	.001	3	1
BLCA	RNU6-1086P →	+0.682	+5.251	<.001	.006	3	1
BLCA	RPLP1P10 →	+0.166	+5.497	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 105 associations by consensus.

MIR3648-1 by EXOSC8 expression — COAD

Explore this box plot interactively →