EXOSC7

Across TCGA patient cohorts, EXOSC7 mutation is significantly associated with the RNA expression of many other genes, with 1,502 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXOSC7-associated genes across cancer lineages are ATP6V1D, ENO2, and AKR1A1. Each is linked with EXOSC7 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXOSC7-to-partner and partner-to-EXOSC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP6V1D grouped by EXOSC7-low versus EXOSC7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOSC7→partner) and Y-score (partner→EXOSC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATP6V1D →	+0.493	+2.700	<.001	.005	3	2
UCEC	ENO2 →	+0.967	+2.233	<.001	.005	3	2
UCEC	AKR1A1 →	+0.401	+3.724	<.001	<.001	3	2
UCEC	OCM →	-0.207	-2.804	.004	.002	3	2
UCEC	TUBG1 →	+0.647	+3.332	<.001	<.001	3	2
READ	NPLP1 →	+0.291	+5.421	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,502 associations by consensus.

ATP6V1D by EXOSC7 expression — UCEC

Explore this box plot interactively →