EXOSC7

Across TCGA pan-cancer cohorts, EXOSC7 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated EXOSC7 data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher EXOSC7 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated EXOSC7 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LGG show a favorable association.

KIRC, ACC, and LIHC are the cancer types where EXOSC7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	III,IV	0.433	0.709	<.001	102	view →
ACC	DFS	Quartile	All	0.270	0.814	<.001	71	view →
LIHC	OS	Median	All	0.617	0.749	.001	49	view →
MESO	OS	Tertile	All	0.174	0.765	.001	45	view →
UCEC	OS	Median	II,III,IV	0.789	0.397	.002	34	view →
CESC	OS	Tertile	IV	0.302	0.765	.008	30	view →
PRAD	DFS	Tertile	All	0.871	0.971	<.001	20	view →
LGG	OS	Median	All	0.602	0.420	.001	19	view →
STAD	DFS	Tertile	IV	0.219	0.718	.006	18	view →
THYM	OS	Median	All	1.000	0.924	.016	17	view →
THCA	DFS	Tertile	All	0.899	0.752	.002	17	view →
PAAD	DFS	Quartile	All	0.340	0.585	.001	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

EXOSC7–KIRC (DFS)

Open the KIRC breakdown →