EXOSC7

Across TCGA patient cohorts, EXOSC7 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXOSC7-associated genes across cancer lineages are PDCD4, PREX1, and ATM. Each is linked with EXOSC7 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXOSC7-to-partner and partner-to-EXOSC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by EXOSC7-low versus EXOSC7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOSC7→partner) and Y-score (partner→EXOSC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.537	-1.990	.003	.030	3	2
UCEC	PREX1 →	-0.250	-2.459	.020	.018	3	2
UCEC	ATM →	-0.589	-3.308	<.001	.009	3	2
UCEC	BRD4 →	+0.258	+2.584	.014	.010	3	2
SKCM	Smac →	+0.356	+2.824	.030	.036	3	1
UCEC	14-3-3_beta →	-0.087	-3.295	.027	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

PDCD4 by EXOSC7 expression — UCEC

Explore this box plot interactively →