Across TCGA patient cohorts, EXOSC6 protein abundance is significantly associated with the RNA expression of many other genes, with 12,688 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible EXOSC6-associated genes across cancer lineages are KIF18A, CENPE, and CENPH. Each is linked with EXOSC6 in more than 6 cancer types. Because this analysis shows association rather than direction, both EXOSC6-to-partner and partner-to-EXOSC6 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOSC6→partner) and Y-score (partner→EXOSC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KIF18A →	+0.898	+0.222	<.001	<.001	3	7
LSCC	CENPE →	+0.918	+0.353	<.001	<.001	3	7
GBM	CENPH →	+1.003	+0.351	<.001	<.001	3	7
LSCC	MAD2L1 →	+0.900	+0.304	<.001	<.001	3	7
GBM	ORC6 →	+0.869	+0.350	<.001	<.001	3	7
UCEC	ANP32B →	+0.737	+0.252	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,688 associations by consensus.

Exploration

EXOSC6 survival (RNA) · tumor vs normal (RNA) · all EXOSC6 data types