Across TCGA pan-cancer cohorts, EXOSC6 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated EXOSC6 data layer compared with 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher EXOSC6 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated EXOSC6 expression acts as an unfavorable survival marker, although some lineages such as SCLC and PAAD show a favorable association.

HNSC, ACC, and SCLC are the cancer types where EXOSC6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.706	0.803	.003	56	view →
ACC	DFS	Tertile	All	0.365	0.744	<.001	50	view →
SCLC	DFS	Median	II,III,IV	0.819	0.205	.004	48	view →
LIHC	DFS	Quartile	All	0.302	0.496	.001	38	view →
KIRP	DFS	Tertile	IV	0.045	0.435	.004	30	view →
PAAD	OS	Tertile	All	0.627	0.295	<.001	22	view →
LUSC	DFS	Median	III,IV	0.248	0.528	.003	20	view →
UVM	DFS	Median	All	0.289	0.627	.032	13	view →
ESCA	DFS	Median	All	0.407	0.574	.017	12	view →
DLBC	DFS	Tertile	III,IV	0.194	1.000	.010	8	view →
PRAD	DFS	Tertile	All	0.888	0.690	.015	8	view →
READ	OS	Quartile	II,III,IV	0.453	1.000	.016	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

Exploration

Same gene, other analysis: EXOSC6 tumor-vs-normal RNA expression · all EXOSC6 data types