EXOSC5

Across TCGA patient cohorts, EXOSC5 protein abundance is significantly associated with the RNA expression of many other genes, with 10,152 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible EXOSC5-associated genes across cancer lineages are ANP32B, NOL10, and CMAHP. Each is linked with EXOSC5 in more than 4 cancer types. Because this analysis shows association rather than direction, both EXOSC5-to-partner and partner-to-EXOSC5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EXOSC5 versus ANP32B in LSCC, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOSC5→partner) and Y-score (partner→EXOSC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ANP32B →	+0.917	+0.297	<.001	<.001	3	5
LSCC	NOL10 →	+0.555	+0.297	<.001	<.001	3	4
LSCC	CMAHP →	-0.863	-0.291	<.001	<.001	3	4
LSCC	UTP4 →	+0.491	+0.161	<.001	<.001	3	4
LSCC	RRM2 →	+0.997	+0.278	<.001	<.001	3	4
OV	EXOSC9 →	+0.511	+0.308	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,152 associations by consensus.

EXOSC5 vs ANP32B — LSCC

Explore this scatter interactively →