EXOSC5

Across TCGA pan-cancer cohorts, EXOSC5 RNA differs between tumor and matched normal tissue in 18 of 18 cancer types tested, making tumor–normal expression one of EXOSC5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where EXOSC5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EXOSC5 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, COAD, and KIRP are the cancer types where EXOSC5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EXOSC5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	+1.678	<.001	12	view →
COAD	Female	II,III,IV	+1.940	<.001	11	view →
KIRP	Male	II,III,IV	+1.302	<.001	10	view →
LUSC	Female	All	+1.748	<.001	9	view →
LIHC	Male	II,III,IV	+1.389	<.001	9	view →
STAD	All	II,III,IV	+1.265	<.001	9	view →
LUAD	All	III,IV	+1.204	<.001	9	view →
BLCA	All	III,IV	+0.938	<.001	8	view →
HNSC	Male	IV	+0.755	<.001	8	view →
BRCA	All	III,IV	+0.795	<.001	6	view →
UCEC	All	All	+0.554	.002	6	view →
THCA	All	II,III,IV	+0.488	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 18 lineages.

EXOSC5–KIRC

Open the KIRC breakdown →