EXOSC5

Across TCGA cell cohorts, EXOSC5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,542 significant associations in total. CNS shows the largest number of these associations.

The most reproducible EXOSC5-associated GO terms across cancer lineages are U4 snRNA 3'-end processing, rRNA metabolic process, and sno(s)RNA 3'-end processing. Each is linked with EXOSC5 in more than 15 cancer types. Because this analysis shows association rather than direction, both EXOSC5-to-partner and partner-to-EXOSC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, U4 snRNA 3'-end processing grouped by EXOSC5-low versus EXOSC5-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOSC5→partner) and Y-score (partner→EXOSC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	U4 snRNA 3'-end processing →	+0.150	+0.911	<.001	<.001	3	16
PANCREAS	rRNA metabolic process →	+0.102	+1.064	<.001	<.001	3	14
PANCREAS	sno(s)RNA 3'-end processing →	+0.138	+1.243	<.001	<.001	3	14
PANCREAS	sno(s)RNA processing →	+0.138	+1.243	<.001	<.001	3	14
SOFT_TISSUE	Maturation of 5.8S rRNA →	+0.108	+0.925	<.001	<.001	3	14
SOFT_TISSUE	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.119	+1.012	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,542 associations by consensus.

U4 snRNA 3'-end processing by EXOSC5 expression — BONE

Explore this box plot interactively →