EXOSC3

Across TCGA patient cohorts, EXOSC3 protein abundance is significantly associated with the RNA expression of many other genes, with 15,422 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible EXOSC3-associated genes across cancer lineages are TAF5, CENPH, and EZH2. Each is linked with EXOSC3 in more than 5 cancer types. Because this analysis shows association rather than direction, both EXOSC3-to-partner and partner-to-EXOSC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EXOSC3 versus TAF5 in BRCA, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOSC3→partner) and Y-score (partner→EXOSC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TAF5 →	+0.535	+0.233	<.001	.001	3	6
GBM	CENPH →	+1.041	+0.344	<.001	<.001	3	6
BRCA	EZH2 →	+1.154	+0.322	<.001	<.001	3	6
UCEC	TOP2A →	+1.080	+0.272	<.001	.001	3	6
BRCA	CDCA8 →	+0.962	+0.222	<.001	<.001	3	6
UCEC	BRIP1 →	+0.717	+0.244	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,422 associations by consensus.

EXOSC3 vs TAF5 — BRCA

Explore this scatter interactively →