EXOC5

Across TCGA pan-cancer cohorts, EXOC5 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated EXOC5 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher EXOC5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated EXOC5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, LUAD, and UCEC are the cancer types where EXOC5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	II,III,IV	0.772	0.488	.002	49	view →
LUAD	OS	Quartile	All	0.321	0.983	.003	38	view →
UCEC	DFS	Quartile	All	1.000	0.725	.001	16	view →
CCRCC	DFS	Median	III,IV	1.000	0.451	.032	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

EXOC5–HNSC (DFS)

Open the HNSC breakdown →