EXOC5

Across TCGA pan-cancer cohorts, EXOC5 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of EXOC5’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where EXOC5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EXOC5 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where EXOC5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EXOC5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	II,III,IV	+0.892	<.001	11	view →
THCA	All	II,III,IV	−0.540	<.001	8	view →
LIHC	All	All	+0.368	<.001	6	view →
CHOL	All	II,III,IV	+1.475	<.001	4	view →
KIRP	Female	II,III,IV	+0.639	.043	2	view →
KICH	Female	All	−0.539	.011	2	view →
BRCA	All	II,III,IV	+0.189	.013	2	view →
READ	Female	All	−0.722	.008	1	view →
ESCA	All	All	+0.436	.036	1	view →
LUSC	All	All	+0.218	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

EXOC5–HNSC

Open the HNSC breakdown →