EXOC5

Across TCGA patient cohorts, EXOC5 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXOC5-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with EXOC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXOC5-to-partner and partner-to-EXOC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by EXOC5-low versus EXOC5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOC5→partner) and Y-score (partner→EXOC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.437	-1.874	.004	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.783	+2.584	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.101	-2.295	.002	.005	3	1
UCEC	eEF2 →	+0.319	+2.584	.007	.010	3	1
UCEC	EGFR_pY1068 →	-0.310	-2.201	<.001	<.001	3	1
UCEC	EGFR →	-0.135	-2.295	.011	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

ATM by EXOC5 expression — UCEC

Explore this box plot interactively →