EXOC2

Across TCGA patient cohorts, EXOC2 mutation is significantly associated with the RNA expression of many other genes, with 2,298 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXOC2-associated genes across cancer lineages are HDGFL2, TYMSOS, and NCAPH2. Each is linked with EXOC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both EXOC2-to-partner and partner-to-EXOC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HDGFL2 grouped by EXOC2-low versus EXOC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOC2→partner) and Y-score (partner→EXOC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HDGFL2 →	+0.407	+4.021	<.001	<.001	3	3
UCEC	TYMSOS →	+0.584	+2.917	<.001	<.001	3	3
UCEC	NCAPH2 →	+0.539	+1.947	<.001	<.001	3	3
UCEC	LIG1 →	+0.416	+1.732	.001	.001	3	3
UCEC	FAHD2A →	+0.287	+1.768	.002	.004	3	3
UCEC	EXOSC8 →	+0.367	+2.098	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,298 associations by consensus.

HDGFL2 by EXOC2 expression — UCEC

Explore this box plot interactively →