EXOC2

Across TCGA cell cohorts, EXOC2 mutation is significantly associated with the RNA expression of many other genes, with 53 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EXOC2-associated genes across cancer lineages are TRIM60, MFRP, and CLPS. Each is linked with EXOC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXOC2-to-partner and partner-to-EXOC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM60 grouped by EXOC2-low versus EXOC2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXOC2→partner) and Y-score (partner→EXOC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TRIM60 →	+0.005	+4.217	<.001	.001	3	1
SKIN	MFRP →	+0.021	+3.684	<.001	.006	3	1
LUNG_NSCLC_LUAD	CLPS →	+0.163	+4.662	<.001	.005	3	1
LUNG_SCLC	SMCP →	+0.038	+4.058	<.001	.007	3	1
LUNG_SCLC	LALBA →	+0.085	+4.684	<.001	<.001	3	1
LUNG_SCLC	OR10AC1 →	+0.061	+4.684	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

TRIM60 by EXOC2 expression — SKIN

Explore this box plot interactively →